Low sodium cotransport in red cells with physiological internal sodium concentration in essential hypertension.
نویسندگان
چکیده
منابع مشابه
Low sodium cotransport in red cells with physiological internal sodium concentration in essential hypertension.
Ouabain-resistant Na and Li effluxes in erythrocytes from 18 normal subjects and 19 hypertensive subjects were studied in fresh cells that contained about 9 mmol Li and 2.5 or 6.5 mmol Na per liter of erythrocytes after intact cells had been incubated for 5 hours in 110 mM Li, 40 mM Na medium, with or without ouabain 10(-4) M. Outward Na cotransport was estimated at both internal Na concentrati...
متن کاملRed cell lithium-sodium countertransport and sodium-potassium cotransport in patients with essential hypertension.
Alterations in sodium countertransport and cotransport have been reported in red cells of patients with essential hypertension. We have investigated the relationship between these two systems by performing simultaneous measurements of the maximal rates of lithium-sodium (Li1-Na0) countertransport and outward sodium-potassium (Na-K) cotransport in red cells from normotensive and hypertensive sub...
متن کاملSodium-potassium cotransport activity as genetic marker in essential hypertension.
Sodium-potassium cotransport activity is thought to be defective in essential hypertension and could be a useful genetic marker for susceptibility to essential hypertension. In this study cotransport activity in subjects with hypertension was compared with that in normotensive controls. The effects of ethnic differences, environment, and antihypertensive drugs were also studied. Mean cotranspor...
متن کاملRed Cell Cotransport Activity and Sodium Content in Black Men Relationship to Essential Hypertension
Furosemide-sensitive sodium and potassium cotransport and intracellular sodium content ([Na],) were measured in erythrocytes (red blood cells, RBCs) from a population of 90 adult black men with and without essential hypertension (EH). The mean values for sodium cotransport activity, expressed as furosemide-sensitive Na efflux (mmol/liter RBC/hr), were not significantly different among the EH pa...
متن کاملAssessment of red cell sodium transport in essential hypertension.
Abnormal erythrocyte Na+ transport has been reported in patients with essential hypertension and some first-degree relatives. The two major techniques now employed for estimating Na+ transport--Na+/Li+ countertransport and Na+/K+ cotransport--are rather intricate and time consuming. Furthermore, the precise nature of the transport processes being measured is not clear. We have developed a simpl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 1984
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.6.6.826